We have very limited TV reception (no cable) and got out of the habit of using the TV for anything other than watching DVDs (... and the Simpsons... and Scrubs reruns)--but I had a friend who really loved Wonderfalls, so I know that it's awesome, and I remember hearing really good reviews of Pushing Daisies on NPR.

It was totally easy to keep the characters apart! They were all very clear characters. The only thing I don't know, of course, is all their backstories, but within the context of this story, they were very distinct and easy to know.